Redox cycling of potential antitumor aziridinyl quinones
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چکیده
منابع مشابه
Activation of hepatocyte protein kinase C by redox-cycling quinones.
The effects of quinone-generated active oxygen species on rat hepatocyte protein kinase C were investigated. The specific activity of cytosolic protein kinase C was increased 2-3-fold in hepatocytes incubated with the redox-cycling quinones, menadione, duroquinone or 2,3-dimethoxy-1,4-naphthoquinone, without alterations in particulate protein kinase C specific activity or Ca2+- and lipid-indepe...
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Quinones are a class of compounds which have widespread importance in chemistry, biology and medicine. Because of their appropriate performance in electron transferring rate, quinones are among the most applicable mediators in biosensors. Recently, the effects of different non-metal substitutions on redox potential of quinone have been investigated to design suitable mediators for different ele...
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Short-chain quinones are described as potent antioxidants and in the case of idebenone have already been under clinical investigation for the treatment of neuromuscular disorders. Due to their analogy to coenzyme Q10 (CoQ10), a long-chain quinone, they are widely regarded as a substitute for CoQ10. However, apart from their antioxidant function, this provides no clear rationale for their use in...
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The redox potentials of the two electron transfer (ET) active quinones in the central part of photosystem I (PSI) were determined by evaluating the electrostatic energies from the solution of the Poisson-Boltzmann equation based on the crystal structure. The calculated redox potentials are -531 mV for A1A and -686 mV for A1B. From these results we conclude the following. (i) Both branches are a...
متن کاملthe effect of coinage transition metal (cu, ag, au) substitutions on two-electron redox potential of quinones
quinones are a class of compounds which have widespread importance in chemistry, biology and medicine. because of their appropriate performance in electron transferring rate, quinones are among the most applicable mediators in biosensors. recently, the effects of different non-metal substitutions on redox potential of quinone have been investigated to design suitable mediators for different ele...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 1992
ISSN: 0891-5849
DOI: 10.1016/0891-5849(92)90034-e